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Virus-Related Muscle Damage Tied to Chronic
Fatigue
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31 October 2003
Reuters - Health
NEW YORK (Reuters Health) - Chronic fatigue syndrome seems
to occur sometimes after a virus infection. Now, researchers
have shown that some patients with the syndrome have
evidence of virus in their muscles, and this in turn is linked to
abnormal muscle function.
Dr. R. J. M. Lane and others at Imperial College in London, UK,
looked for RNA from enteroviruses in muscle biopsies taken
from 48 patients with chronic fatigue syndrome and from 29
people with normal muscles
Muscle biopsy samples from 10 of the 48 chronic fatigue
patients were positive for enterovirus RNA, Lane's team reports
in the Journal of Neurology, Neurosurgery, and Psychiatry. "All
29 human tissue controls...were negative for enterovirus
sequences."
The investigators say the RNA most closely that from coxsackie
B virus.
In addition, the patients with chronic fatigue syndrome went
through an exercise test on the day of the biopsy, and the
researchers measured the patients' blood levels of lactic acid
before and after the test.
Twenty-eight patients had an abnormal lactate response to
exercise, "reflecting impaired muscle energy metabolism."
Moreover, 9 of the 10 subjects who tested positive for the
presence of virus in their muscles had this abnormal response.
The team concludes that their findings support the notion that
chronic fatigue syndrome has different causes, "and that some
cases have a peripheral component to their fatigue related to
muscle dysfunction."
SOURCE: Journal of Neurology, Neurosurgery, and Psychiatry,
October 1, 2003.
Copyright © 2003 Reuters Limited
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End of ME-NET Digest - 31 Oct 2003 to 1 Nov
2003 - Special issue (#2003-409)
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